IL1RL1 Protein (AA 1-328) (Fc Tag)
Quick Overview for IL1RL1 Protein (AA 1-328) (Fc Tag) (ABIN1344266)
Target
See all IL1RL1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-328
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Purification tag / Conjugate
- This IL1RL1 protein is labelled with Fc Tag.
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Purpose
- ST2 (human):Fc (human) (rec.)
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Specificity
- Binds to human IL-33.
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Cross-Reactivity
- Human
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Characteristics
- Signal peptide and the sequence of isoform 2 of human ST2 (aa 1-328) are fused at the C-terminus to the Fc portion of human IgG1.
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Sterility
- Sterile filtered
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Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
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Biological Activity Comment
- Interacts with human IL-33.
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Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) (Active) protein (His tag)
IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 1 Receptor-Like 1 (IL1RL1) protein (His tag)IL1RL1 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) protein (His tag)IL1RL1 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) protein (His tag)IL1RL1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-323) (Active) protein (Fc Tag)IL1RL1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- 0.2μm-filtered solution in PBS, pH 7.2.
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Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))
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Alternative Name
- ST2
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Background
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Interleukin-1 Receptor-like 1, IL-1 Receptor-like 1, IL1RL1, IL-33 Receptor, Interleukin-33 Receptor
The ST2 (Interleukin-1 receptor-like 1, Interleukin-33 receptor) gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signaling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.
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Molecular Weight
- ~90kDa (SDS-PAGE)
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UniProt
- Q01638
Target
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