MESP1 Protein
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- Target See all MESP1 Proteins
- MESP1 (Mesoderm Posterior 1 (MESP1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Insect Cells
- Sequence
- MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL LETWMPLSPL EWLPEEPK
- Characteristics
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Length (AA): 268
Chromosomal location: 15q26.1 - Purity
- > 95 % by SDS-PAGE. Visualized by silver stain
- Top Product
- Discover our top product MESP1 Protein
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Mesoderm Posterior 1 (MESP1) (AA 1-63) protein (GST tag)
MESP1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Mesoderm Posterior 1 (MESP1) (AA 1-268) protein (Strep Tag)Crystallography grade MESP1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) (AA 1-243) protein (Strep Tag)Crystallography grade MESP1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Mesoderm Posterior 1 (MESP1) protein (Myc-DYKDDDDK Tag)MESP1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Not determined yet.
- Comment
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Cytokines & Growth Factors
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Human MesP1 should be reconstituted in sterile water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- Buffer
- 0.5X PBS
- Handling Advice
- Freeze/thaw cycles will result in significant loss of activity.
- Storage
- 0 °C
- Storage Comment
- The lyophilized human MesP1, though stable at room temperature, is best stored desiccated below 0 °C.
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- Target
- MESP1 (Mesoderm Posterior 1 (MESP1))
- Alternative Name
- MesP1 (MESP1 Products)
- Synonyms
- bHLHc5 Protein, mesp Protein, mesp1 Protein, mespa Protein, CMESO-1 Protein, CMESO2 Protein, MESP1 Protein, mesoderm posterior 1 Protein, mesoderm posterior bHLH transcription factor 1 Protein, mesoderm posterior 1 homolog (mouse) Protein, mesoderm posterior homolog B Protein, mesoderm posterior homolog B L homeolog Protein, Mesp1 Protein, MESP1 Protein, mesp1 Protein, mespb Protein, mespb.L Protein
- Background
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ES-cell-based cardiovascular repair requires an in-depth understanding of the molecular mechanisms underlying the differentiation of cardiovascular ES cells. A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1 (1,2). As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is required for cardiac morphogenesis (2,3). It was shown that MesP1 is a key factor sufficient to induce the formation of ectopic heart tissue in vertebrates and increase cardiovasculogenesis by ES cells. Electrophysiological analysis showed all subtypes of cardiac ES-cell differentiation (4). MesP1 overexpression and knockdown experiments revealed a prominent function of MesP1 in a gene regulatory cascade, causing Dkk-1-mediated blockade of canonical Wnt-signalling. Independent evidence from ChIP and in vitro DNA-binding studies, expression analysis in wild-type and MesP knockout mice, and reporter assays confirm that Dkk-1 is a direct target of MesP1.
Synonyms: MESP1, bHLHc5 - Molecular Weight
- 34 kDa
- NCBI Accession
- NM_018670, NP_061140
- UniProt
- Q9BRJ9
- Pathways
- Regulation of Muscle Cell Differentiation
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