IL-6 Receptor Protein (C-Term, Extracellular Domain)

Catalog No. ABIN1684654

This Recombinant IL-6 Receptor protein is produced in HEK-293T Cells.

Quick Overview for IL-6 Receptor Protein (C-Term, Extracellular Domain) (ABIN1684654)

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293T Cells

Purity: > 97 %, as determined by SDS-PAGE and HPLC

Product Details

Protein Characteristics: C-Term, Extracellular Domain

Specificity: Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.

Characteristics: Recombinant mouse IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Application Details

Restrictions: For Research Use only

Handling

Buffer: PBS solution, pH7.2.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.

Expiry Date: 12-24 months

Target Details

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: CD126

Background: Neurotrophin-3 is found in neurons of the central nervous system. NT-3 is expressed also in muscles and its expression is down-regulated in denervated muscles. Many human gliomas express and secrete NT-3 into the conditioned medium.ome protein domains of NT-3 are identical with those of NGF and BDNF. NT-3 selectively supports the survival of neuronal cell populations. NT-3 has been shown recently to prevent death of cultured embryonic rat spinal motor neurons at picomolar concentrations. NT-3 has been shown to enhance sprouting of corticospinal tract during development and after adult spinal cord lesion. The activities of NT-3 and BDNF are additive in some systems. The biological activities of NT-3 are mediated by a receptor belonging to the trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 only binds weakly to the trk receptor which is a high-affinity receptor for NGF.

UniProt: P22272

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints