Neuroligin 4 Protein (NLGN4) (AA 42-676) (His tag)

Catalog No. ABIN1691472

Recombinant Neuroligin 4 protein expressed in Human Cells.

Quick Overview for Neuroligin 4 Protein (NLGN4) (AA 42-676) (His tag) (ABIN1691472)

Target: Neuroligin 4 (NLGN4)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 42-676

Purification tag / Conjugate: This Neuroligin 4 protein is labelled with His tag.

Purpose: Recombinant Human Neuroligin 4, X-Linked/NLGN4X (C-6His)

Sequence: QAQYPVVNTN YGKIRGLRTP LPNEILGPVE QYLGVPYASP PTGERRFQPP EPPSSWTGIR NTTQFAAVCP QHLDERSLLH DMLPIWFTAN LDTLMTYVQD QNEDCLYLNI YVPTEDDIHD QNSKKPVMVY IHGGSYMEGT GNMIDGSILA SYGNVIVITI NYRLGILGFL STGDQAAKGN YGLLDQIQAL RWIEENVGAF GGDPKRVTIF GSGAGASCVS LLTLSHYSEG LFQKAIIQSG TALSSWAVNY QPAKYTRILA DKVGCNMLDT TDMVECLRNK NYKELIQQTI TPATYHIAFG PVIDGDVIPD DPQILMEQGE FLNYDIMLGV NQGEGLKFVD GIVDNEDGVT PNDFDFSVSN FVDNLYGYPE GKDTLRETIK FMYTDWADKE NPETRRKTLV ALFTDHQWVA PAVATADLHA QYGSPTYFYA FYHHCQSEMK PSWADSAHGD EVPYVFGIPM IGPTELFSCN FSKNDVMLSA VVMTYWTNFA KTGDPNQPVP QDTKFIHTKP NRFEEVAWSK YNPKDQLYLH IGLKPRVRDH YRATKVAFWL ELVPHLHNLN EIFQYVSTTT KVPPPDMTSF PYGTRRSPAK IWPTTKRPAI TPANNPKHSK DPHKTGPEDT TVLIETKRDY STELSVDHHH HHH

Characteristics: Recombinant Human Neuroligin 4, X-Linked/NLGN4X is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln42-Ser676) of Human NLGN4X fused with a polyhistidine tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: Neuroligin 4 (NLGN4)

Sub Type: Fusionprotein

Background: Neuroligin 4, X-Linked (NLGN4X) is a single-pass type I membrane protein that belongs to the type-B carboxylesterase/lipase family. NLGN4X is detected at higher levels in heart and at lower levels in the liver, skeletal muscle, and pancreas. NLGN4X is a putative neuronal cell surface protein involved in cell-cell-interactions. NLGN4X may act as splice site-specific ligands for beta-neurexins. It has been shown that NLGN4X is involved in the formation and remodeling of central nervous system synapses. NLGN4X also interacts with discs, large (Drosophila) homolog 4 (DLG4). Defects in NLGN4X have been associated with autism and Asperger syndrome.
Alternative Names: Neuroligin-4 X-Linked, Neuroligin X, HNLX, NLGN4X, KIAA1260, NLGN4

Molecular Weight: 72.46 kDa

UniProt: Q8N0W4

Pathways: Cell-Cell Junction Organization, Synaptic Membrane