IRF5 Protein (AA 1-498) (His tag)

Catalog No. ABIN1691985

Recombinant IRF5 protein expressed in Escherichia coli (E. coli).

Quick Overview for IRF5 Protein (AA 1-498) (His tag) (ABIN1691985)

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: >90% by SDS-PAGE

Product Details

Protein Characteristics: AA 1-498

Purification tag / Conjugate: This IRF5 protein is labelled with His tag.

Purpose: Recombinant Human Interferon Regulatory Factor 5/IRF5 (C-6His)

Sequence: MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQLE HHHHHH

Characteristics: Recombinant Human Interferon Regulatory Factor 5 is produced by our E.coli expression system and the target gene encoding Met1-Gln498 is expressed with a 6His tag at the C-terminus.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 1 EU/ug

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 30% Glycerol, 1mM DTT, pH8.0

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IRF5 (Interferon Regulatory Factor 5 (IRF5))

Alternative Name: IRF5

Sub Type: Fusionprotein

Background: Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in susceptibility to rheumatoid arthritis.
Alternative Names: Interferon Regulatory Factor 5, IRF-5, IRF5

UniProt: Q13568

Pathways: TLR Signaling, Autophagy