IRF5 Protein (AA 1-498) (His tag)
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- Target See all IRF5 Proteins
- IRF5 (Interferon Regulatory Factor 5 (IRF5))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-498
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IRF5 protein is labelled with His tag.
- Purpose
- Recombinant Human Interferon Regulatory Factor 5/IRF5 (C-6His)
- Sequence
- MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQLE HHHHHH
- Characteristics
- Recombinant Human Interferon Regulatory Factor 5 is produced by our E.coli expression system and the target gene encoding Met1-Gln498 is expressed with a 6His tag at the C-terminus.
- Purity
- >90% by SDS-PAGE
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 1 EU/ug
- Top Product
- Discover our top product IRF5 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 30% Glycerol, 1mM DTT, pH8.0
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IRF5 (Interferon Regulatory Factor 5 (IRF5))
- Alternative Name
- IRF5 (IRF5 Products)
- Synonyms
- IRF5 Protein, irf5 Protein, SLEB10 Protein, AW491843 Protein, mirf5 Protein, im:7155364 Protein, zgc:76986 Protein, interferon regulatory factor 5 Protein, interferon regulatory factor 5 L homeolog Protein, IRF5 Protein, irf5 Protein, Irf5 Protein, irf5.L Protein
- Sub Type
- Fusionprotein
- Background
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Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in susceptibility to rheumatoid arthritis.
Alternative Names: Interferon Regulatory Factor 5, IRF-5, IRF5 - UniProt
- Q13568
- Pathways
- TLR Signaling, Autophagy
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