Endoglin Protein (ENG) (AA 26-176) (His-TRX)
Quick Overview for Endoglin Protein (ENG) (AA 26-176) (His-TRX) (ABIN1692461)
Target
See all Endoglin (ENG) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 26-176
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Purification tag / Conjugate
- This Endoglin protein is labelled with His-TRX.
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Purpose
- Recombinant Human Endoglin/CD105 (N-Trx, 6His)
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Sequence
- MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL KEFLDANLAG SGSGHMHHHH HHSSGLVPRG SGMKETAAAK FERQHMDSPD LGTDDDDKAM ETVHCDLQPV GPERDEVTYT TSQVSKGCVA QAPNAILEVH VLFLEFPTGP SQLELTLQAS KQNGTWPREV LLVLSVNSSV FLHLQALGIP LHLAYNSSLV TFQEPPGVNT TELPSFPKTQ ILEWAAERGP ITSAAELNDP QSILLRLGQA Q
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Characteristics
- Recombinant Human Endoglin is produced by our E.coli expression system and the target gene encoding Glu26-Gln176 is expressed with a Trx, 6His tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Endoglin (ENG) (AA 26-586) (Active) protein (His-Avi Tag)
ENG Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Endoglin (ENG) (AA 1-658) protein (GST tag)ENG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Endoglin (ENG) (AA 27-658) protein (GST tag)ENG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Endoglin (ENG) (AA 394-581) protein (His-IF2DI Tag)ENG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Endoglin (ENG) (AA 27-581) (Active) protein (His tag)ENG Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS, AcA Active
Endoglin (ENG) (AA 26-586) protein (His tag)ENG Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
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Restrictions
- For Research Use only
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Format
- Liquid
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Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Supplied as a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
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Handling Advice
- minimize freeze-thaw cycles
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- Endoglin (ENG)
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Alternative Name
- Endoglin
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Sub Type
- Fusionprotein
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Background
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Alternative Names: Endoglin, END, CD105, ENGEndoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins and/or other RGD receptors. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1), which is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations.
Alternative Names: Endoglin, END, CD105, ENG -
Molecular Weight
- 33.6 kDa
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UniProt
- P17813
Target
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