Free PSA Protein
Quick Overview for Free PSA Protein (ABIN1880349)
Target
Protein Type
Biological Activity
Origin
Source
Application
Purity
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 0.01 M PBS ( pH 7.4±0.2) without preservative.
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Preservative
- Without preservative
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Shipat 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- Free PSA (fPSA) (Free Prostate Specific Antigen (fPSA))
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Alternative Name
- Free PSA
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Background
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Synonyms: Prostate specific antigen, PSA, gamma-seminoprotein, Seminin, Kallikrein-3, P30 antigen, Semenogelase, KLK3, APS
Description: Purified human Free PSA protein.
Background: Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.
Target
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