Glypican 3 Protein (GPC3)
Quick Overview for Glypican 3 Protein (GPC3) (ABIN1880377)
Target
See all Glypican 3 (GPC3) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Glypican 3 (GPC3) (AA 99-330) protein (Fc Tag)
GPC3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Glypican 3 (GPC3) (AA 25-559) (Active) protein (Biotin,His-Avi Tag)GPC3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Glypican 3 (GPC3) (AA 25-559) (Active) protein (His tag)GPC3 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Glypican 3 (GPC3) (AA 438-554) (Active) protein-VLPGPC3 Origin: Human Host: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Glypican 3 (GPC3) (AA 25-559) (Active) protein (Fc Tag)GPC3 Origin: Cynomolgus Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE Func Active
Glypican 3 (GPC3) (AA 25-559) (Active) protein (His tag,AVI tag,Biotin)GPC3 Origin: Human Host: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
Glypican 3 (GPC3) (AA 25-559) (Active) protein (Fc Tag)GPC3 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE Func Active
Glypican 3 (GPC3) (AA 25-559) (Active) protein (His tag)GPC3 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Glypican 3 (GPC3) (AA 25-559) protein (His tag)GPC3 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Glypican 3 (GPC3) protein (His tag)GPC3 Origin: Rhesus Monkey Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 10 mM Tris-HCL( pH 8.8±0.2) with 0.05 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- Glypican 3 (GPC3)
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Alternative Name
- Glypican-3
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Background
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Synonyms: Glypican-3, GPC3, GTR2-2, Intestinal protein OCI-5, MXR7, OCI5
Description: Recombinant full length human GPC3 protein.
Background: Glypican 3, GPC3 is a member of the glypican family that are heparan sulfate proteoglycans that bind to the exocytoplasmic surface of the plasma membrane through a covalent glycosylphosphatidylinositol (GPI) linkage. GPC3 gene contains 8 exons and encompasses approximately 500 kb. It encodes a putative extracellular proteoglycan, glypican 3, that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development and that the overgrowth observed in SGBS (Simpson-Golabi-Behmel overgrowth syndrome) patients is, at least in part, the consequence of hyperactivation of the Hedgehog signaling pathway.
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Pathways
- Glycosaminoglycan Metabolic Process
Target
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