OB Cadherin Protein (AA 23-617) (Fc Tag,His tag)

Catalog No. ABIN1880628

Product Details

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Protein Type: Recombinant

Protein Characteristics: AA 23-617

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This OB Cadherin protein is labelled with Fc Tag,His tag.

Purpose: Recombinant Human Cadherin-11/OB-Cadherin/CDH11 (C-Fc-6His)

Sequence: FAPERRGHLR PSFHGHHEKG KEGQVLQRSK RGWVWNQFFV IEEYTGPDPV LVGRLHSDID SGDGNIKYIL SGEGAGTIFV IDDKSGNIHA TKTLDREERA QYTLMAQAVD RDTNRPLEPP SEFIVKVQDI NDNPPEFLHE TYHANVPERS NVGTSVIQVT ASDADDPTYG NSAKLVYSIL EGQPYFSVEA QTGIIRTALP NMDREAKEEY HVVIQAKDMG GHMGGLSGTT KVMITLTDVN DNPPKFPQSV YQMSVSEAAV PGEEVGRVKA KDPDIGENGL VTYNIVDGDG MESFEITTDY ETQEGVIKLK KPVDFETKRA YSLKVEAANV HIDPKFISNG PFKDTVTVKI AVEDADEPPM FLAPSYIHEV QENAAAGTVV GRVHAKDPDA ANSPIRYSID RHTDLDRFFT INPEDGFIKT TKPLDREETA WLNITVFAAE IHNRHQEAKV PVAIRVLDVN DNAPKFAAPY EGFICESDQT KPLSNQPIVT ISADDKDDTA NGPRFIFSLP PEIIHNPNFT VRDNRDNTAG VYARRGGFSR QKQDLYLLPI VISDGGIPPM SSTNTLTIKV CGCDVNGALL SCNAEAYILN AGLSTVDDIE GRMDEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

Characteristics: Recombinant Human Cadherin-11/ CDH11 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Phe23-Thr617) ofHuman CDH11 fused with a FC-6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Alternative Name: CDH11 (CDH11 Products)

Synonyms: cad11 Protein, cdhob Protein, osf-4 Protein, Xcad-11 Protein, MGC108014 Protein, OB-cadherin Protein, cadherin-11 Protein, Cad11 Protein, cdhvn Protein, vnc Protein, CAD11 Protein, CDHOB Protein, OB Protein, OSF-4 Protein, cadherin 11 Protein, cadherin 11, type 2, OB-cadherin (osteoblast) Protein, cadherin 11 S homeolog Protein, CDH11 Protein, cdh11 Protein, Cdh11 Protein, cdh11.S Protein

Background: Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. It is shown that cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.

Molecular Weight: 93.5 kDa

UniProt: Q96CZ9