Betacellulin Protein (BTC) (AA 32-111)
Quick Overview for Betacellulin Protein (BTC) (AA 32-111) (ABIN2017692)
Target
See all Betacellulin (BTC) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 32-111
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Characteristics
- ED50 <0.08 ng/mL, measured in a cell proliferation assay using 3T3 cells.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Betacellulin (BTC) (AA 1-178) protein (GST tag)
BTC Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Betacellulin (BTC) (AA 32-111) protein (His tag)BTC Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (Fc Tag)BTC Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant murine Betacellulin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine Betacellulin should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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Expiry Date
- 6 months
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- Betacellulin (BTC)
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Alternative Name
- Betacellulin
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Background
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Betacellulin, also known as BTC, belongs to the EGF family of growth factors. It is expressed in many tissues, such as kidney, pancreas and small intestine. Betacellulin is initially synthesized as a membrane-bound precursor containing multiple EGF-like domains in its extracellular region, and is released from the membrane by proteolytic cleavage. BTC is the ligand for EGFR/ErbB receptor tyrosine kinases, and plays a role in cell growth and differentiation. BTC has been reported to promote beta cell growth and differentiation in the pancreas. Pancreas-specific expression of this gene may induce islet neogenesis and remediate hyperglycemia in type I diabetes.
Synonyms: BTC -
Molecular Weight
- 19-24 kDa, observed by reducing SDS-PAGE.
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UniProt
- Q543J8
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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