GDNF Protein (AA 77-211)
Quick Overview for GDNF Protein (AA 77-211) (ABIN2017883)
Target
See all GDNF ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 77-211
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Characteristics
- ED50 <8 μg /mL, measured in a bioassay using C6 cells.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein
GDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (His tag)GDNF Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 78-211) protein (Fc Tag)GDNF Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Glial Cell Line Derived Neurotrophic Factor (GDNF) (AA 1-211) protein (GST tag)GDNF Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
Glial Cell Line Derived Neurotrophic Factor (GDNF) proteinGDNF Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant murine GDNF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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Expiry Date
- 6 months
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- GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))
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Background
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Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson's Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
Synonyms: Glial-Derived Neurotrophic Factor, ATF-1 -
Molecular Weight
- 17-22 kDa, observed by reducing SDS-PAGE.
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UniProt
- P48540
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Pathways
- RTK Signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration
Target
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