Interleukin 17a Protein (AA 26-158)
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- Target See all Interleukin 17a (IL17A) Proteins
- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-158
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Origin
- Mouse
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Source
- CHO Cells
- Characteristics
- Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes.
- Purity
- > 95 % as analyzed by SDS-PAGE.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL17A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Murine Interleukin-17A (IL-17A) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, recombinant murine IL-17A should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
- Alternative Name
- Interleukin-17A (IL-17A) (IL17A Products)
- Synonyms
- CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein
- Background
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Interleukin-17A, (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. Recombinant murine IL-17A is a 15-20 kDa glycosylated cytokine of 133 amino acid polypeptide chain that plays an important role in antimicrobial and chronic inflammation. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cell proliferation.
Synonyms: IL-17A, CTLA-8 - Molecular Weight
- 15-22 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q62386
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