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IL-2 Protein (AA 21-153)

This Recombinant IL-2 protein is produced in CHO Cells.
Catalog No. ABIN2018088

Quick Overview for IL-2 Protein (AA 21-153) (ABIN2018088)

Target

See all IL-2 (IL2) Proteins
IL-2 (IL2) (Interleukin 2 (IL2))

Protein Type

Recombinant

Biological Activity

Active

Origin

  • 46
  • 26
  • 9
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Source

  • 50
  • 29
  • 23
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
CHO Cells

Purity

> 95 % as analyzed by SDS-PAGE.
  • Protein Characteristics

    AA 21-153

    Characteristics

    ED50 < 2 ng/mL, measured in a cell proliferation assay using CTLL-2 cells.

    Endotoxin Level

    < 0.2 EU/μg, determined by LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Reconstituted in ddH2O or PBS at 100 μg/mL.

    Buffer

    Lyophilized after extensive dialysis against PBS..

    Storage

    -80 °C

    Storage Comment

    Lyophilized recombinant Human Interleukin-2 (IL-2) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-2 (IL-2) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

    Expiry Date

    6 months
  • Target

    IL-2 (IL2) (Interleukin 2 (IL2))

    Alternative Name

    Interleukin-2 (IL-2)

    Background

    Interleukin-2 (IL-2) is a Oglycosylated, four alpha-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma delta T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes.
    Synonyms: T-cell growth factor (TCGF), Aldesleukin

    Molecular Weight

    15-16 kDa, observed by reducing SDS-PAGE.

    UniProt

    P60568

    Pathways

    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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