Quick Overview for NOG Protein (AA 28-232) (ABIN2018291)
Target
See all NOG ProteinsProtein Type
Biological Activity
Origin
Source
Purity
-
-
Protein Characteristics
- AA 28-232
-
Characteristics
- ED50<2.5 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.
-
Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
Noggin (NOG) (AA 20-232) (Active) protein
NOG Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) (AA 28-232) proteinNOG Origin: Human Host: CHO Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Noggin (NOG) protein (His tag)NOG Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (His tag)NOG Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Noggin (NOG) (AA 28-232) protein (GST tag)NOG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Noggin (NOG) (AA 28-232) protein (Fc Tag)NOG Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
-
Buffer
- Lyophilized after extensive dialysis against PBS.
-
Storage
- -80 °C
-
Storage Comment
- Lyophilized recombinant human Noggin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.
-
Expiry Date
- 6 months
-
-
- NOG (Noggin (NOG))
-
Alternative Name
- Noggin
-
Background
-
Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Synonyms: NOG -
Molecular Weight
- 29-31kDa, observed by reducing SDS-PAGE.
-
UniProt
- Q13253
-
Pathways
- Stem Cell Maintenance, Tube Formation
Target
-
