Thrombopoietin Protein (THPO) (AA 22-356)

Catalog No. ABIN2018397

Recombinant Thrombopoietin protein expressed in CHO Cells.

Quick Overview for Thrombopoietin Protein (THPO) (AA 22-356) (ABIN2018397)

Target: Thrombopoietin (THPO)

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: CHO Cells

Purity: > 95 % as analyzed by SDS-PAGE.

Product Details

Protein Characteristics: AA 22-356

Characteristics: ED50 < 2 ng /mL, measured in a proliferation assay using MO7e cells.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL..

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant murine Thrombopoietin (TPO) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Thrombopoietin (TPO) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: Thrombopoietin (THPO)

Alternative Name: Thrombopoietin (TPO)

Background: Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

Molecular Weight: 30-80 kDa, observed by reducing SDS-PAGE.

UniProt: P40226

Pathways: JAK-STAT Signaling, Hormone Activity