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TFF3 Protein

TFF3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN2018418
  • Target See all TFF3 Proteins
    TFF3 (Trefoil Factor 3 (Intestinal) (TFF3))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 9
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Source
    • 16
    • 4
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequence
    EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF
    Characteristics
    Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human MCF-7 cells is less than 10 μg/mL, corresponding to a specific activity of > 100 IU/mg.
    Purity
    > 95 % by SDS-PAGE and HPLC analyses.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    < 1 EU/μg of rHuTFF3 as determined by LAL method.
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    Discover our top product TFF3 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
    Buffer
    Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.
  • Target
    TFF3 (Trefoil Factor 3 (Intestinal) (TFF3))
    Alternative Name
    Trefoil Factor 3(TFF3) (TFF3 Products)
    Background
    The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.
    Synonyms: Trefoil Factor 3 Human, TFF3 Human
    Molecular Weight
    6.6 kDa, a single non-glycosylated polypeptide chain containing 59 amino acids, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
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