Pleiotrophin Protein (PTN)
Quick Overview for Pleiotrophin Protein (PTN) (ABIN935709)
Target
See all Pleiotrophin (PTN) ProteinsProtein Type
Origin
Source
Purity
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Sequence
- GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
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Characteristics
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Purified recombinant Human Pleiotrophin protein
Expression System: E.coli -
Endotoxin Level
- < 0.1 ng per μg (1 EU/μg).
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Pleiotrophin (PTN) (AA 33-168) protein (Fc Tag)
PTN Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Pleiotrophin (PTN) protein (His tag)PTN Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Pleiotrophin (PTN) (AA 33-168) protein (Fc Tag)PTN Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Pleiotrophin (PTN) (AA 1-168) protein (GST tag)PTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Pleiotrophin (PTN) (Active) proteinPTN Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
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Buffer
- Lyophilized from 5 mM Na3PO4, pH 7.4.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Pleiotrophin (PTN)
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Alternative Name
- Pleiotrophin
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Background
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Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas.
Alternative Names: HBGF-8 protein, PTN protein, OSF-1 protein, HARP protein, Osteoblast-Specific Factor-1 protein, Heparin-binding growth factor-8protein, Heparin Affin Regulatory Protein protein -
Molecular Weight
- 15.4 kDa
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Pathways
- RTK Signaling
Target
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