Thyroperoxidase Protein (full length)

Catalog No. ABIN2132174

This Recombinant Thyroperoxidase protein is produced in Insect cells (Sf9).

Quick Overview for Thyroperoxidase Protein (full length) (ABIN2132174)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Protein Type: Recombinant

Origin: Human

Source: Insect cells (Sf9)

Application: Western Blotting (WB), ELISA

Purity: > 95 % pure

Product Details

Protein Characteristics: full length

Characteristics: Purified recombinant Human Thyroid Peroxidase protein
Expression System: Sf-9 insect cells

Purification: Proprietary chromatographic technique

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 16 mM HEPES, pH 7.6, with 166 mM NaCl, 0.06 mM Kl and 20 % glycerol.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid Peroxidase

Background: Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3.
Alternative Names: TPX protein, MSA protein, TPO protein

Molecular Weight: 101 kDa

Pathways: Thyroid Hormone Synthesis