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CTLA4 Protein (Cytotoxic T-Lymphocyte-Associated Protein 4) (AA 37-160) (Fc Tag)

CTLA4 Origin: Human Host: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Catalog No. ABIN2180932
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  • Target See all CTLA4 Proteins
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 37-160
    Origin
    • 31
    • 15
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    Human
    Source
    • 26
    • 15
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CTLA4 protein is labelled with Fc Tag.
    Sequence
    AA 37-160
    Characteristics
    This protein carries a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 40 kDa. The predicted N-terminus is Ala 37. As a result of glycosylation, the reducing (R) protein migrates as 50-55 kDa, and the non-reducing (NR) protein migrates as 100-110 kDa in SDS-PAGE.
    Purity
    >98 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

  • Target
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Alternative Name
    CTLA-4 (CTLA4 Products)
    Synonyms
    CTLA-4, CTLA4, CD152, Cd152, Ctla-4, Ly-56, CD, CELIAC3, GRD4, GSE, IDDM12, sCTLA4, cytotoxic T-lymphocyte associated protein 4, cytotoxic T-lymphocyte-associated protein 4, CTLA4, Ctla4
    Background
    CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
    Molecular Weight
    39.9 kDa
    NCBI Accession
    NP_005205
    Pathways
    Cancer Immune Checkpoints
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