Decorin Protein (DCN) (AA 17-359) (His tag)
Quick Overview for Decorin Protein (DCN) (AA 17-359) (His tag) (ABIN2180962)
Target
See all Decorin (DCN) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 17-359
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Purification tag / Conjugate
- This Decorin protein is labelled with His tag.
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Sequence
- AA 17-359
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.8 kDa. The protein migrates as 45 kDa or higher under reducing (R) condition (SDS-PAGE) due to different glycosylation.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- Decorin (DCN)
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Alternative Name
- Decorin
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Background
- Decorin is also known as bone proteoglycan II, PGS2, SLRR1B, DCN, DSPG2 and PG40, is a secreted chondroitin /dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. Decorin appears to influence fibrillogenesis, and also interacts with fibronectin, thrombospondin, the complement component C1q, epidermal growth factor receptor (EGFR) and transforming growth factor-beta (TGF-beta). Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD).
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Molecular Weight
- 38.8 kDa
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NCBI Accession
- NP_001911
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Pathways
- Glycosaminoglycan Metabolic Process
Target
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