FZD5 Protein (AA 27-167) (Fc Tag)

Catalog No. ABIN2181128

This Recombinant FZD5 protein is expressed in HEK-293 Cells and has been mentioned in 1 publication.

Quick Overview for FZD5 Protein (AA 27-167) (Fc Tag) (ABIN2181128)

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 27-167

Purification tag / Conjugate: This FZD5 protein is labelled with Fc Tag.

Sequence: AA 27-167

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

References

Peterson, Nasarre, Bonilla, Hilliard, Samples, Morinelli, Hill, Klauber-DeMore: "Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis." in: Angiogenesis, Vol. 20, Issue 4, pp. 615-628, (2018) (PubMed).

Target Details

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Alternative Name: Frizzled-5

Background: Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Molecular Weight: 42.6 kDa

UniProt: Q13467

Pathways: WNT Signaling