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FZD7 Protein (AA 33-185) (Fc Tag)

This Recombinant FZD7 protein is produced in HEK-293 Cells.
Catalog No. ABIN2181130
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Quick Overview for FZD7 Protein (AA 33-185) (Fc Tag) (ABIN2181130)

Target

FZD7 (Frizzled Family Receptor 7 (FZD7))

Protein Type

Recombinant

Origin

  • 9
  • 2
Human

Source

  • 5
  • 3
  • 1
  • 1
  • 1
HEK-293 Cells

Purity

>92 % as determined by SDS-PAGE.
  • Protein Characteristics

    AA 33-185

    Purification tag / Conjugate

    This FZD7 protein is labelled with Fc Tag.

    Sequence

    AA 33-185

    Characteristics

    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    Sterility

    0.22 μm filtered

    Endotoxin Level

    Less than 1.0 EU per μg by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    Tris with Glycine, Arginine and NaCl,  pH 7.5

    Handling Advice

    Please avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target

    FZD7 (Frizzled Family Receptor 7 (FZD7))

    Alternative Name

    Frizzled-7

    Background

    Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

    Molecular Weight

    43.3 kDa

    Pathways

    WNT Signaling, Stem Cell Maintenance
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