FZD7 Protein (AA 33-185) (Fc Tag)
Quick Overview for FZD7 Protein (AA 33-185) (Fc Tag) (ABIN2181130)
Target
Protein Type
Origin
Source
Purity
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Protein Characteristics
- AA 33-185
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Purification tag / Conjugate
- This FZD7 protein is labelled with Fc Tag.
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Sequence
- AA 33-185
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Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- FZD7 (Frizzled Family Receptor 7 (FZD7))
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Alternative Name
- Frizzled-7
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Background
- Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.
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Molecular Weight
- 43.3 kDa
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Pathways
- WNT Signaling, Stem Cell Maintenance
Target
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