Betacellulin Protein (BTC)
Quick Overview for Betacellulin Protein (BTC) (ABIN2468275)
Target
See all Betacellulin (BTC) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY
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Characteristics
- Biological activity was determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is < 0.01 ng/mL, corresponding to a specific activity of > 1 x 108 units/mg.
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Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Betacellulin (BTC) (AA 1-178) protein (GST tag)
BTC Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Betacellulin (BTC) (AA 32-111) protein (His-IF2DI Tag)BTC Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (His-IF2DI Tag)BTC Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (Fc Tag)BTC Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing Betacellulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Betacellulin stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- Betacellulin (BTC)
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Alternative Name
- Betacellulin
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Background
- Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
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Gene ID
- 12223
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NCBI Accession
- NP_031594
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OMIM
- 6680812
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UniProt
- Q05928
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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