Endonuclease G Protein (ENDOG) (AA 51-140) (His tag,Strep II tag)
Quick Overview for Endonuclease G Protein (ENDOG) (AA 51-140) (His tag,Strep II tag) (ABIN2468369)
Target
See all Endonuclease G (ENDOG) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 51-140
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Purification tag / Conjugate
- This Endonuclease G protein is labelled with His tag,Strep II tag.
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Endonuclease G (ENDOG) (AA 50-297) protein (GST tag)
ENDOG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Endonuclease G (ENDOG) (AA 23-212) protein (His-IF2DI Tag)ENDOG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Endonuclease G (ENDOG) (AA 1-294) (Active) protein (His tag,GST tag)ENDOG Origin: Rat Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
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Application Notes
- This recombinant protein can be used for WB, ELISA, MS.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 1X PBS containing 0.1 % SDS and 0.02 % NaN
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -80 °C
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Storage Comment
- Store in working aliquots at -70 °C.
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- Endonuclease G (ENDOG)
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Alternative Name
- EndoG
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Background
- The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribo-nuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1-3). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndoG also cleaves DNA in vitro (4).
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Molecular Weight
- 15 kDa (Calculated)
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Gene ID
- 2021
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OMIM
- 24638471
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UniProt
- Q14249
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Pathways
- Apoptosis
Target
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