RCAN2 Protein (AA 2-197, Isoform 2) (His tag)
Quick Overview for RCAN2 Protein (AA 2-197, Isoform 2) (His tag) (ABIN2469007)
Target
See all RCAN2 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Isoform 2, AA 2-197
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Purification tag / Conjugate
- This RCAN2 protein is labelled with His tag.
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Regulator of Calcineurin 2 (RCAN2) (AA 1-225) protein (GST tag)
RCAN2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Regulator of Calcineurin 2 (RCAN2) (AA 1-197) protein (His-IF2DI Tag)RCAN2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Regulator of Calcineurin 2 (RCAN2) (AA 1-197) protein (His tag)RCAN2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
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Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 100 mM sodium phosphate, 10 mM Tris, 500 mM NaCl, 25 mM imidazole, 2 mM MgCl2, 10 % gycerol
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Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -80 °C
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Storage Comment
- Store in working aliquots at -70 °C.
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- RCAN2 (Regulator of Calcineurin 2 (RCAN2))
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Alternative Name
- RCAN2
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Background
- Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle (1,2). Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin s activity (3). Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3 (3). RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome (4).
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Molecular Weight
- 26 kDa (Calculated)
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Gene ID
- 53901
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OMIM
- 38328420
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UniProt
- Q9JHG2
Target
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