RANK Receptor (Soluble) (Active) Protein
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
< 98 % by SDS-PAGE gel and HPLC analyses.
Active
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- Target
- RANK Receptor
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Soluble
- Origin
- Human
- Source
- Escherichia coli (E. coli)
- Sequence
- MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
- Characteristics
- Biological activity was determined by its ability to suppress the production of IFN - gamma from human PBMCs.
- Purity
- < 98 % by SDS-PAGE gel and HPLC analyses.
- Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Handling Advice
- As with any protein, exposing Soluble RANK Receptor recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -20 °C
- Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Soluble RANK Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- Expiry Date
- 24 months
-
- Target
- RANK Receptor
- Background
- RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na ve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).
- Gene ID
- 8792
- NCBI Accession
- NP_001257878
- OMIM
- 401015111
- UniProt
- Q9Y6Q6
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