Thrombopoietin Protein (THPO)
Quick Overview for Thrombopoietin Protein (THPO) (ABIN2469139)
Target
See all Thrombopoietin (THPO) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
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Characteristics
- The ED50 was determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be < 0.2 ng/mL, corresponding to a specific activity of > 5 x 107 units/mg.
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Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Thrombopoietin (THPO) (AA 22-356) (Active) protein
THPO Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Thrombopoietin (THPO) protein (His tag)THPO Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Thrombopoietin (THPO) (AA 23-195) protein (His tag)THPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 22-195) protein (His-IF2DI Tag)THPO Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 1-349) protein (GST tag)THPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing Thrombopoeitin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Thrombopoeitin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- Thrombopoietin (THPO)
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Background
- TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
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Gene ID
- 81811
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NCBI Accession
- NP_112395
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OMIM
- 13592113
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UniProt
- P49745
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Pathways
- JAK-STAT Signaling, Hormone Activity
Target
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