TRAIL Protein
Quick Overview for TRAIL Protein (ABIN2469171)
Target
See all TRAIL (TNFSF10) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN
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Characteristics
- Biological activity was determined by the dose - dependent stimulation of MIP - 2 production by mouse spleen cells using a concentration range of 10 - 100 ng/mL.
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Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 118-281), (Trimer) protein (His-DYKDDDDK Tag)
TNFSF10 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-291) protein (His tag)custom-made TNFSF10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-281) protein (His tag)custom-made TNFSF10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 1-281) protein (GST tag)TNFSF10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) protein (His-DYKDDDDK-Strep II Tag)TNFSF10 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 118-291) protein (His tag)TNFSF10 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) proteinTNFSF10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 95-281) protein (His-IF2DI Tag)TNFSF10 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) proteinTNFSF10 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90,00% SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing TRAIL recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted TRAIL is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
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Alternative Name
- TRAIL
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Background
- TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain , which activates the cell s apoptotic machinery. Recombinant murine soluble TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.
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Gene ID
- 22035
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NCBI Accession
- NP_033451
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OMIM
- 6678431
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UniProt
- P50592
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Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity
Target
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