DR4 Protein (His tag)

Catalog No. ABIN2566511

Recombinant DR4 protein expressed in HEK-293 Cells.

Quick Overview for DR4 Protein (His tag) (ABIN2566511)

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Western Blotting (WB)

Purity: >92 % as determined by SDS-PAGE.

Product Details

Purification tag / Conjugate: This DR4 protein is labelled with His tag.

Application Details

Application Notes: This recombinant protein can be used for WB. For research use only.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -80 °C,-20 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Target Details

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Alternative Name: DR4

Background: Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

Molecular Weight: 24 kDa

Gene ID: 8797

NCBI Accession: NP_003835

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity