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CXCL11 Protein (AA 22-100)

CXCL11 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. MA Active
Catalog No. ABIN2666636
  • Target See all CXCL11 Proteins
    CXCL11 (Chemokine (C-X-C Motif) Ligand 11 (CXCL11))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-100
    Origin
    • 8
    • 3
    • 2
    • 1
    • 1
    Mouse
    Source
    • 10
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Multiplex Assay (MA)
    Purity
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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    Discover our top product CXCL11 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Biological activity: Bioactivity was measured by its property to chemoattract Baf3-hCXCR3 transfectants in a dose dependent manner.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored from -20 °C to -70 °C. Stock solutions can also be prepared at 50-100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
    Buffer
    0.22 μm filtered protein solution is in PBS.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
  • Target
    CXCL11 (Chemokine (C-X-C Motif) Ligand 11 (CXCL11))
    Alternative Name
    CXCL11 (CXCL11 Products)
    Synonyms
    H174 Protein, I-TAC Protein, IP-9 Protein, IP9 Protein, SCYB11 Protein, SCYB9B Protein, b-R1 Protein, Cxc11 Protein, I-tac Protein, Ip9 Protein, Itac Protein, Scyb11 Protein, Scyb9b Protein, betaR1 Protein, C-X-C motif chemokine ligand 11 Protein, chemokine (C-X-C motif) ligand 11 Protein, CXCL11 Protein, Cxcl11 Protein
    Background
    CXCL11 is a CXC chemokine lacking the ELR (Glutamate-Leucine-Arginine) tripeptide motif, which is functionally and structurally related to CXCL9 and CXCL10. CXCL11, together with CXCL9 and CXCL10, specifically binds to the G protein-coupled receptor CXCR3 and is involved in chemotaxis of immune cells and angiogenesis. Expression of both CXCR3 and CXCL11 by the Th1-associated cytokine IFNγ creates an amplification loop of cell-mediated immune response between Th1 cells. CXCR7 has been identified as an alternate receptor for CXCL11 and is involved in growth, survival, and adhesion of tumor cells.
    Molecular Weight
    The 80 amino acid recombinant protein has a predicted molecular mass of approximately 9.1 kDa. The DTT-reduced protein migrates at approximately 11 kDa and non-reduced protein migrates at approximately 13 kDa by SDS-PAGE. The N-terminal amino acid is Meth
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