Lamin A/C Protein (LMNA)

Catalog No. ABIN2669331

Recombinant Lamin A/C protein expressed in Escherichia coli (E. coli).

Quick Overview for Lamin A/C Protein (LMNA) (ABIN2669331)

Target: Lamin A/C (LMNA)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Characteristics: Recombinant human lamin A is a 645 amino acids protein with a molecular weight of 70 kDa.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM phosphate buffer pH 7.0, 0.5M NaCl, 1 mM DTT, 1.5 mM EDTA, 20 % (v/v) glycerol

Storage: -20 °C

Target Details

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A

Background: Lamin A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA). Lamin A is synthesized as a longer precursor, prelamin A (code REP0038), that in vivo undergoes to serial post-translational modifications that lead to mature lamin A. Different mutations in the LMNA gene have been associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus