COMT Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)
Quick Overview for COMT Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag) (ABIN2712475)
Target
See all COMT ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 4
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Purification tag / Conjugate
- This COMT protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human COMT (transcript variant 4) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Catechol-O-Methyltransferase (COMT) (AA 1-271) protein (His tag)
custom-made COMT Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Catechol-O-Methyltransferase (COMT) (AA 1-265) protein (His tag)custom-made COMT Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Catechol-O-Methyltransferase (COMT) (AA 1-182) protein (GST tag)COMT Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Catechol-O-Methyltransferase (COMT) (AA 51-271) protein (His-IF2DI Tag)COMT Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Catechol-O-Methyltransferase (COMT) (AA 51-271) proteinCOMT Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- COMT (Catechol-O-Methyltransferase (COMT))
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Alternative Name
- Comt
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Background
- Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
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Molecular Weight
- 24.3 kDa
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NCBI Accession
- NP_009294
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Pathways
- Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome
Target
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