Cyclin D2 Protein (CCND2) (Myc-DYKDDDDK Tag)
Quick Overview for Cyclin D2 Protein (CCND2) (Myc-DYKDDDDK Tag) (ABIN2712725)
Target
See all Cyclin D2 (CCND2) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Cyclin D2 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Cyclin D2 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Cyclin D2 (CCND2) (AA 1-289) protein (His tag)
custom-made CCND2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D2 (CCND2) (AA 1-289) protein (His tag)custom-made CCND2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D2 (CCND2) (AA 1-289) protein (GST tag)CCND2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Cyclin D2 (CCND2)
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Alternative Name
- Cyclin d2
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Background
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
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Molecular Weight
- 32.9 kDa
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NCBI Accession
- NP_001750
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Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
Target
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