F11R Protein

Catalog No. ABIN2713651

Product Details

Target: F11R (F11 Receptor (F11R))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CD321 / JAM1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin Level: < 0.1 EU per μg protein as determined by LAL test

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Restrictions: For Research Use only

Handling

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 100 mM Glycine, pH 7.5. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: F11R (F11 Receptor (F11R))

Alternative Name: Cd321,jam1 (F11R Products)

Synonyms: CD321 Protein, JAM Protein, JAM1 Protein, JAMA Protein, JCAM Protein, KAT Protein, PAM-1 Protein, 9130004G24 Protein, AA638916 Protein, ESTM33 Protein, JAM-1 Protein, JAM-A Protein, Jcam Protein, Jcam1 Protein, Ly106 Protein, Jam1 Protein, F11 receptor Protein, F11R Protein, F11r Protein

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5&apos alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Molecular Weight: 23.9 kDa

NCBI Accession: NP_058642

Pathways: Cell-Cell Junction Organization