Catalog No. ABIN2713871
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20 μg
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Quick Overview for CDK8 Protein (Myc-DYKDDDDK Tag) (ABIN2713871)
Target
See all CDK8 Proteins
CDK8
(Cyclin-Dependent Kinase 8 (CDK8))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Purification tag / Conjugate
- This CDK8 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human CDK8 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Cyclin-Dependent Kinase 8 (CDK8) (AA 375-464) protein (GST tag)
CDK8 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
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Alternative Name
- Cdk8
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Background
- This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
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Molecular Weight
- 53.1 kDa
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NCBI Accession
- NP_001251
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Pathways
- Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
Target
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