ASXL1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714399

Recombinant ASXL1 protein expressed in HEK-293 Cells.

Quick Overview for ASXL1 Protein (Myc-DYKDDDDK Tag) (ABIN2714399)

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Purification tag / Conjugate: This ASXL1 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Additional sex combs like 1 (ASXL1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Background: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Molecular Weight: 9.4 kDa

NCBI Accession: NP_001158075

Pathways: Retinoic Acid Receptor Signaling Pathway