APLP2 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714847

This Recombinant APLP2 protein is produced in HEK-293 Cells.

Quick Overview for APLP2 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag) (ABIN2714847)

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 3

Purification tag / Conjugate: This APLP2 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human APPL2 / APLP2 (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Alternative Name: Appl2,aplp2

Background: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer&aposs disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 79.1 kDa

NCBI Accession: NP_001135749

Pathways: EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour