APPL2 Protein (Myc-DYKDDDDK Tag)
Quick Overview for APPL2 Protein (Myc-DYKDDDDK Tag) (ABIN2714848)
Target
See all APPL2 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This APPL2 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human APPL2 / DIP13B protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) protein (GST tag)
APPL2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 403-664) protein (His tag)APPL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
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Alternative Name
- Appl2,dip13b
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Background
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(1222)(q24.1q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
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Molecular Weight
- 74.3 kDa
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NCBI Accession
- NP_060641
Target
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