BCCIP Protein (Transcript Variant B) (Myc-DYKDDDDK Tag)
Quick Overview for BCCIP Protein (Transcript Variant B) (Myc-DYKDDDDK Tag) (ABIN2715186)
Target
See all BCCIP ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant B
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Purification tag / Conjugate
- This BCCIP protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human BCCIP / TOK1 (transcript variant B) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-314) protein (GST tag)
BCCIP Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-314) protein (His-IF2DI Tag)BCCIP Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
BRCA2 and CDKN1A Interacting Protein (BCCIP) (AA 1-314) protein (His tag)BCCIP Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))
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Alternative Name
- Bccip,tok1
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Background
- This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
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Molecular Weight
- 35.8 kDa
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NCBI Accession
- NP_510868
Target
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