BCL2L1 Protein (Transcript Variant 2)
Quick Overview for BCL2L1 Protein (Transcript Variant 2) (ABIN2715193)
Target
See all BCL2L1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 2
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Characteristics
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- Recombinant human Bcl-2-like 1 (transcript variant 2) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
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Endotoxin Level
- < 0.1 EU per μg protein as determined by LAL test
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BCL2-Like 1 (BCL2L1) (AA 1-233) protein (His tag)
custom-made BCL2L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2-Like 1 (BCL2L1) (AA 1-233) protein (His tag)custom-made BCL2L1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2-Like 1 (BCL2L1) (AA 1-209) protein (His tag)BCL2L1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
BCL2-Like 1 (BCL2L1) (AA 1-212) protein (His tag)BCL2L1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
BCL2-Like 1 (BCL2L1) (AA 1-212) protein (Fc Tag)BCL2L1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
BCL2-Like 1 (BCL2L1) (AA 1-233) protein (GST tag)BCL2L1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Like 1 (BCL2L1) (AA 1-212) (Active) protein (His tag)BCL2L1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE Active
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 20 mM HEPES, 50 mM KCl, 20 % Glycerol, pH 7.5. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- BCL2L1 (BCL2-Like 1 (BCL2L1))
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Alternative Name
- Bcl-2-Like 1
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Background
- The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
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Molecular Weight
- 24.8 kDa
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NCBI Accession
- NP_001182
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Pathways
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
Target
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