BCR Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
This Recombinant BCR protein is expressed in HEK-293 Cells.
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Catalog No. ABIN2715211
$1,112.40
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20 μg
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United States
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Quick Overview for BCR Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2715211)
Target
See all BCR Proteins
BCR
(Breakpoint Cluster Region (BCR))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This BCR protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human BCR (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- BCR (Breakpoint Cluster Region (BCR))
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Alternative Name
- Bcr
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Background
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
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Molecular Weight
- 137.5 kDa
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NCBI Accession
- NP_067585
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Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
Target
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