DUSP12 Protein (Myc-DYKDDDDK Tag)
Quick Overview for DUSP12 Protein (Myc-DYKDDDDK Tag) (ABIN2719827)
Target
See all DUSP12 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This DUSP12 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human DUSP12 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Dual Specificity Phosphatase 12 (DUSP12) (AA 1-340) protein (His tag)
custom-made DUSP12 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Dual Specificity Phosphatase 12 (DUSP12) (AA 1-340) protein (GST tag)DUSP12 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))
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Alternative Name
- Dusp12
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Background
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
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Molecular Weight
- 37.5 kDa
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NCBI Accession
- NP_009171
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Pathways
- Regulation of Carbohydrate Metabolic Process
Target
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