EDARADD Protein (Transcript Variant B) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2719929

This Recombinant EDARADD protein is produced in HEK-293 Cells.

Quick Overview for EDARADD Protein (Transcript Variant B) (Myc-DYKDDDDK Tag) (ABIN2719929)

Target: EDARADD (EDAR-Associated Death Domain (EDARADD))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant B

Purification tag / Conjugate: This EDARADD protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human EDARADD (transcript variant B) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: EDARADD (EDAR-Associated Death Domain (EDARADD))

Alternative Name: Edaradd

Background: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 23.5 kDa

NCBI Accession: NP_542776

Pathways: Ubiquitin Proteasome Pathway