FKBP1A Protein (Transcript Variant 12A) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2721206

Recombinant FKBP1A protein expressed in HEK-293 Cells.

Quick Overview for FKBP1A Protein (Transcript Variant 12A) (Myc-DYKDDDDK Tag) (ABIN2721206)

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 12A

Purification tag / Conjugate: This FKBP1A protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human FKBP1A / FKBP12 (transcript variant 12A) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: Fkbp1a,fkbp12

Background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Molecular Weight: 11.8 kDa

NCBI Accession: NP_463460

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process