Quick Overview for XIAP Protein (Myc-DYKDDDDK Tag) (ABIN2723210)
Target
See all XIAP ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This XIAP protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human IAP3 / BIRC4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497) protein (His tag)
custom-made XIAP Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
X-Linked Inhibitor of Apoptosis (XIAP) (AA 120-356) protein (His-IF2DI Tag)XIAP Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
X-Linked Inhibitor of Apoptosis (XIAP) (AA 1-497), (full length) protein (His-SUMO Tag)XIAP Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- XIAP (X-Linked Inhibitor of Apoptosis (XIAP))
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Alternative Name
- Iap3,birc4
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Background
- This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].
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Molecular Weight
- 56.5 kDa
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NCBI Accession
- NP_001158
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Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
Target
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