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Isocitrate Dehydrogenase Protein (IDH) (Myc-DYKDDDDK Tag)

IDH Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2723840
  • Target See all Isocitrate Dehydrogenase (IDH) Proteins
    Isocitrate Dehydrogenase (IDH)
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    • 1
    Human
    Source
    • 3
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Isocitrate Dehydrogenase protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Isocitrate dehydrogenase / IDH protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product IDH Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Isocitrate Dehydrogenase (IDH)
    Alternative Name
    Isocitrate Dehydrogenase,idh (IDH Products)
    Synonyms
    CG7176 Protein, CT22171 Protein, Dmel\\CG7176 Protein, IDH Protein, IDH-NADP Protein, Idh-NADP Protein, idh Protein, isocitrate dehydrogenase Protein, l(3)L3852 Protein, F20D21.16 Protein, F20D21_16 Protein, SMU.672 Protein, icd Protein, Isocitrate dehydrogenase Protein, isocitrate dehydrogenase Protein, isocitrate dehydrogenase, NADP-dependent Protein, Monomeric isocitrate dehydrogenase Protein, ankyrin repeat domain 26-like Protein, Idh Protein, ICDH Protein, idh Protein, icd Protein, SSO_RS10660 Protein, JK_RS08640 Protein, LOC618625 Protein
    Background
    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
    Molecular Weight
    46 kDa
    NCBI Accession
    NP_005887
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