Rubicon Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
Quick Overview for Rubicon Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2724189)
Target
See all Rubicon (KIAA0226) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This Rubicon protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human KIAA0226 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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KIAA0226 (KIAA0226) (AA 10-278) protein (His-IF2DI Tag)
KIAA0226 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
KIAA0226 (KIAA0226) (AA 1-375) protein (GST tag)KIAA0226 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Rubicon (KIAA0226) (KIAA0226)
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Alternative Name
- Kiaa0226
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Background
- The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Molecular Weight
- 108.4 kDa
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NCBI Accession
- NP_055502
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Pathways
- Autophagy
Target
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