OAS1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
Quick Overview for OAS1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2727845)
Target
See all OAS1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This OAS1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human OAS1 / OIAS (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (AA 1-400) protein (His tag)
custom-made OAS1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (AA 1-400) protein (GST tag)OAS1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (AA 1-364) protein (His tag)OAS1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
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Alternative Name
- Oas1,oias
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Background
- This gene is induced by interferons and encodes a protein that synthesizes 2&apos,5&apos-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.
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Molecular Weight
- 41.6 kDa
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NCBI Accession
- NP_002525
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Pathways
- Hepatitis C
Target
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