SAV1 Protein (Myc-DYKDDDDK Tag)
Quick Overview for SAV1 Protein (Myc-DYKDDDDK Tag) (ABIN2731426)
Target
See all SAV1 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This SAV1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human SAV1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Salvador Homolog 1 (SAV1) (AA 1-386) protein (His tag)
custom-made SAV1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Salvador Homolog 1 (SAV1) (AA 1-383) protein (His tag)custom-made SAV1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- SAV1 (Salvador Homolog 1 (SAV1))
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Alternative Name
- Sav1
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Background
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
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Molecular Weight
- 44.5 kDa
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NCBI Accession
- NP_068590
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Pathways
- Stem Cell Maintenance
Target
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