Catalog No. ABIN2732750
$1,112.40
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20 μg
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United States
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Quick Overview for STAM Protein (Myc-DYKDDDDK Tag) (ABIN2732750)
Target
See all STAM Proteins
STAM
(Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Purification tag / Conjugate
- This STAM protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human STAM1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) (AA 1-403) protein (GST tag)
STAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
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Alternative Name
- Stam1
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Background
- Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [UniProtKB/Swiss-Prot Function]
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Molecular Weight
- 59 kDa
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NCBI Accession
- NP_003464
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Pathways
- EGFR Signaling Pathway, EGFR Downregulation
Target
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